Transtesticles, also known as transsexuals or transgender people, are individuals that have undergone extensive surgery to change their sex, or identify as the opposite gender. True Capitalist Radio seems to have a larger-than-expected share of listeners in this demographic, which Ghost himself has cottoned on to.
Most of the time, when transtesticles call Ghost, it usually ends up with Ghost getting disgusted and hanging up. Sometimes Ghost has been known to call out bad transtesticles with deep voices, mocking them by doing an uncannily good female voice impression.
For a more thorough look at Ghost's political opinions on transsexuals, see LGBT.
The Original Run
Beginning in September 2011, Ghost received calls from several transtesticles, primarily by Tri$ha/NoteParty. After being disgusted by her advances repeatedly, he was soon greeted with two new trans callers: Tina and Amy Daly. He was genuinely baffled at how his show has attracted a huge contingent of trans callers. As the first couple months of 2012 came to a close, Episode 209 brought this in an unusual direction: Tina and Amy Daly fought over Ghost's affection on-air. However, Tina's time as a caller was on short notice, as she was banned from the show after Episode 214 because Ghost stopped taking her calls altogether.
Since the return, Transtesticles have become a more serious show topic. They have gained more media coverage and are often discussed, especially as relates to laws that were passed in North Carolina which prohibits people from entering the bathroom of the sex they were not designated at birth. Ghost has stated that he is okay with this law, that as long as the Transtesticle can "pass" they'll be fine and that no one would have any reason to question their sex going into the bathroom they desire, but expressing outrage at cross-dressers and fail-trannies who look like men with dresses and use "politricks" to dismantle the notion of gender for no good reason.
Ghost described his reassessment of the transgender movement as a kind of a change of heart. However, his sentiment that transgender issues would be moot if the transtesticles in question put an effort into passing (so that no one would question their choice of bathroom to begin with) echoed an opinion he has held since the original run of the show, such as in Capitalist Episode 151 when discussing Australia acknowledging a "third gender". Ghost does seem less disgusted by the notion of transsexualism as a whole and has expressed his belief in Capitalist Episode 429 that a "gender identity crisis" can be a legitimate struggle. Much of this change of respect was brought on by Amy Daly and Ghost's newfound respect for Amy's investigative journalism and capitalist ventures.
Once a common facet of Ghost's Vocabulary, the self-made epithet "transtesticle" has all but disappeared from True Capitalist Radio since The Return. Ghost has never given a proper explanation for his abandonment of the term, but it may have something to do with his aforementioned change in attitude toward the transgender movement. Ghost acknowledged the change in Capitalist Episode 429 when he officially changed the name of the Ghostie for "Transtesticle of the Year" to "Tranny of the Year", and was quick to assure his audience that he was not "becoming an SJW" by trading a made-up slur, "transtesticle", for a widely used and acknowledged actual slur for transgender people, "tranny".
The Break to Today
Following Amy Daly's ousting from the Inner Circle, Ghost has rekindled his old attitude about transtesticles, and has begun using the term "transtesticle" again in post-The Break episodes. On Gab and on post-break episodes of True Capitalist Radio, he has completely reversed his opinions on them, and now treats the concept as a whole with hostility, reversing his views he originally stated on Episode 151 of True Capitalist Radio. He has also referred to them as "cross-dressers" and "gender-benders" on Gab, along with both transtesticle and tranny. One transtesticle who was from Texas was referred to as a "slag with a meat bag", a shoutout name which Ghost originally reacted to in disgust on Episode 536. After the 2018 Midterm Elections, Ghost has party blamed them for the Republican Party failing to keep control of the House of Representatives.